Oxidase Reactivity of CuII Bound to N-Truncated Aβ Peptides Promoted by Dopamine

N-truncated Aβ peptides in complex fluids unraveled by new specific immunoassays.

Previous studies have highlighted the potential physiopathological and diagnostic role of N- and C-terminally truncated amyloid-β (Aβ) peptides in Alzheimer's disease. However, our knowledge about their production remains incomplete, in part due to the lack of very specific and sensitive tools for their detection. We thus developed specific monoclonal antibodies that target either Aβ11-x or Aβ1...

Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides

The neuropathological hallmarks of Alzheimer's disease include extracellular neuritic plaques and neurofibrillary tangles. The neuritic plaques contain β-amyloid peptides (Aβ peptides) as the major proteinaceous constituent and are surrounded by activated microglia and astrocytes as well as dystrophic neurites. N-terminally truncated forms of Aβ peptides are highly prevalent in neuritic plaques...

One-pot preparation of N,N′-alkylidenebisamides promoted by BF3.SiO2

A highly efficient procedure for the preparation of N,N'-alkylidenebisamides in the presence of BF3.SiO2 as a catalyst is described. N,N'-alkylidenebisamides have been prepared via one-pot three-component condensation reaction of various aldehydes and amides. All of the reactions proceeded in high yields and in moderately short reaction times.

One-pot preparation of N,N′-alkylidenebisamides promoted by BF3.SiO2

A highly efficient procedure for the preparation of N,N'-alkylidenebisamides in the presence of BF3.SiO2 as a catalyst is described. N,N'-alkylidenebisamides have been prepared via one-pot three-component condensation reaction of various aldehydes and amides. All of the reactions proceeded in high yields and in moderately short reaction times.

Peptides in Systemic Lupus T Cell Reactivity to MHC Class II-Bound Self